Preparation of Acetanilide

Synthesis of Acetanilide Reaction O NH2 + H3C C O O C CH3 O N C CH3 H + H3C O C OH Aniline acetic anhydride Acetanilide Acetic acid social function Acetanilide is a useful herald to many pharmaceuticals such as acetaminophen and penicillin. Experimental Procedure. (Estimated time 1. 5 h. ) Unless differently noted, all manipulations should be done in the chemical fume hood. Place nose candy L of aniline into a tared 10 X 75-mm block out tube (standing in a small beaker or Erlenmeyer flask). now add 0. -mL of distilled water with swirling, followed by 3 drops of concentrated hydrochloric acid. Add 10 mg of powdered decolorizing charcoal, or the pelletized form (Norit) to the resulting outcome. check over the test tube with a bottle cork stopper and take it back to your hood. gravity slaver this suspension (25-mm funnel fitted with fluted fast-grade strain paper see instructor) into a 3. 0-mL cone-shaped vial containing a magnetic crack vane. Wet the filter paper in adva nce with distilled water and blot the redundance water from the stem of the funnel.Use an surplus 0. 5 mL of distilled water to rinse the test tube and pass that through the filter paper into your vial. Your aniline hydrochloride solution is construct for reaction. Assemble the apparatus as shown down the stairs CONICAL VIAL W/ magnetic SPIN VANE AND AIR optical condenser Dissolve 150 mg (1. 10 mmol) of sodium acetate trihydrate in 0. 5 mL of distilled water in a 10 X 17-mm test tube. crownwork the tube and set the solution apart for use in the next step. accept Article Free-Radical BrominationAdd, with stirring, 150 L of acetic anhydride to the solution of aniline hydrochloride, followed quickly by addition (Pasteur pipet) of the previously prepared solution of sodium acetate. Stir to thoroughly riffle the reagents (5 min. ). You should see the formation of a white precipitate. Allow the reaction miscellanea to stand at room temperature for rough 5 min and then tail end it in an ice bath for an additional 5-10 min to complete the crystallization process.Collect the phenylacetamide increase by filtration under lessen pressure utilise a Buchner funnel. lave the conical vial with two 0. 5-mL portions of distilled water and use the rinse to wash the tranquil filter cake. Characterization. Weigh and determine the pct yield of the product. Obtain an IR spectrum using the total internal reflectance attachment. agree a 1H NMR of your product if in that respect is not enough we will pool samples together. Take the melting point of the product and compare it to the literature value. BUCHNER FUNNEL